I was skeptical. One pick is more expensive than a set of Jazz III... why? It makes coffee while I playing or what? It is playing instead of me? Ehh, not. 
For the first touch it was a bit odd. I'm a Jazz III fan. 
The Screamer is much bigger, but lighter than the Jazz, so it has a very different feeling. Feels like a mixture of glass and plastic. Overall, it has a good touch and the grip is very good. So far, no drop . 
The sound. I think the difference is very noticeable. The name "Screamer" is quite accurate. Its easier to pick the pitch harmonics and they have a higher pitch. More glassy, crystal-like extra harmonics can be noticed. I not recommend for blues, too bright. Good for metal. 
I've been using for a month and I didn't notice any loss in sharpness. 
 
I think it worth the money, I like it. Probably I will buy a few more and try the other shapes what they offer. But so far... the Screamer became my main pick.